Methyl Indole AM Resin

Methyl Indole AM Resin

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General description
[3-((Methyl-Fmoc-amino)-methyl)indol-1-yl] acetyl AM resin is an extremely useful support for the production of N-methyl substituted carboxamides and sulfonamides, as well as peptide N-methylamides [1]. After first removing the Fmoc group, loading of the resin with Fmoc-amino acids can be effected using HATU/DIPEA. Cleavage with TFA directly provides the product N-methylamide.



Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Literature references

[1] K. G. Estep, et al. (1998) J. Org. Chem., 63, 5300.

Linkage
Replaces: 01-64-0451

Analysis Note
Colour (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.60 – 1.00 mmol/g
Swelling Volume (in CH₂Cl₂): lot specific result
The polymer matrix is copoly (styrene-1 % DVB), 100 – 200 mesh.

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